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The central nervous system toxicity of methotrexate was studied in 6 cases. In all cases, the dosage of methotrexate was reduced by 50% or more of the standard initial dose due to untoward side effects. Two patients had anaphylaxis; another had reversible neurological deterioration. The dose of methotrexate was subsequently reduced in these patients until no untoward effects occurred. Once such a reduction was initiated, a comparable reduction could be made in all cases by a 50% or greater reduction in dose. Methotrexate dosage should be reduced prior to any attempt to initiate long-term therapy for rheumatoid arthritis.Comparison of serum chemiluminescence and haemolytic titre in drug-induced photosensitivity.
Drug-induced photosensitivity is a relatively common syndrome, which presents in a variety of forms. To examine its incidence, we measured serum chemiluminescence and haemolytic titre in 38 hospital patients with a diagnosis of drug-induced photosensitivity. Serum chemiluminescence was measured using a luminol-dependent system ( 0b46394aab
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